abstract：:We compared the mitogenic and signaling pathways of three Fibroblast Growth Factor Receptors (FGFRs), FGFR1, KGFR and FGFR4 in the same cell line. Each receptor was expressed in L6E9 rat myoblasts that do not normally express detectable levels of FGFRs and clones that express comparable levels of each receptor were se...

journal_title：Oncogene

authors： Shaoul E,Reich-Slotky R,Berman B,Ron D

更新日期：1995-04-20 00:00:00

abstract：:The B-raf/c-Rmil proto-oncogene belongs to the raf/mil family of serine/threonine protein kinases. It encodes multiple protein isoforms resulting from alternative splicing of two exons located upstream of the kinase domain. Recent studies suggested that B-Raf could be the intermediate molecule between Ras and Mek-1 (M...

journal_title：Oncogene

authors： Papin C,Eychène A,Brunet A,Pagès G,Pouysségur J,Calothy G,Barnier JV

更新日期：1995-04-20 00:00:00

abstract：:The RBTN1 and RBTN2 genes are activated by distinct translocations involving chromosome 11 in some T cell acute leukaemias. The RBTN proteins belong to the LIM family which comprises proteins with one, two or three cysteine-rich LIM domains, sometimes together with homeodomains or protein kinase domains. The RBTN1 and...

journal_title：Oncogene

authors： Sánchez-García I,Axelson H,Rabbitts TH

更新日期：1995-04-06 00:00:00

abstract：:Burkitt's lymphoma cells are characterized by chromosomal translocations involving the proto-oncogene c-myc on chromosome 8 and one of the immunoglobulin gene loci on chromosome 2, 14 or 22. The translocated c-myc allele is transcriptionally activated, shows a preferential usage of promoter P1 over P2 (promoter shift)...

journal_title：Oncogene

authors： Hörtnagel K,Mautner J,Strobl LJ,Wolf DA,Christoph B,Geltinger C,Polack A

更新日期：1995-04-06 00:00:00

abstract：:An Ets-related E1A-F has been characterized as an enhancer-binding protein for the adenovirus E1A gene. Here we show, in transient expression assays, that E1A-F can activate three different subclasses of the matrix metalloproteinase gene promoters. Expressions of the chloramphenicol acetyltransferase (CAT) reporter ge...

journal_title：Oncogene

authors： Higashino F,Yoshida K,Noumi T,Seiki M,Fujinaga K

更新日期：1995-04-06 00:00:00

abstract：:Tumor suppressor gene CDKN2 (also called MTS1, CDK4I and p16INK4) is located in 9p21 and deleted homozygously in a high percentage of tumor cell lines. We have examined the sequence of CDKN2 in 154 tumor cell lines that are not homozygously deleted for CDKN2. Overall, 18% (27/154) of the cell lines carried mutations i...

journal_title：Oncogene

authors： Liu Q,Neuhausen S,McClure M,Frye C,Weaver-Feldhaus J,Gruis NA,Eddington K,Allalunis-Turner MJ,Skolnick MH,Fujimura FK

更新日期：1995-03-16 00:00:00

abstract：:T-cell antigen receptor stimulation results in phosphorylation of the SH2 containing Shc proteins and recruitment of the Grb2/mSos complex suggesting that Shc proteins are involved in transducing T-cell activating signals to Ras. We have measured the effects of the isolated Shc-SH2 domain and the dominant negative Ras...

journal_title：Oncogene

authors： Baldari CT,Pelicci G,Di Somma MM,Milia E,Giuli S,Pelicci PG,Telford JL

更新日期：1995-03-16 00:00:00

abstract：:FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. It has recently been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. To better understand the role played by FES i...

journal_title：Oncogene

authors： Yates KE,Lynch MR,Wong SG,Slamon DJ,Gasson JC

更新日期：1995-03-16 00:00:00

abstract：:Assessment of the genetic instability of a microsatellite has indicated a new mechanism in human carcinogenesis. Examination was made to determine whether microsatellite instability is associated with the onset of prostate cancer. Twenty-nine DNA samples from 24 primary prostate cancer, two metastatic lymph-node and t...

journal_title：Oncogene

authors： Uchida T,Wada C,Wang C,Ishida H,Egawa S,Yokoyama E,Ohtani H,Koshiba K

更新日期：1995-03-02 00:00:00

abstract：:We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence sim...

journal_title：Oncogene

authors： Fujiwara Y,Ohata H,Kuroki T,Koyama K,Tsuchiya E,Monden M,Nakamura Y

更新日期：1995-03-02 00:00:00

abstract：:Chromosomal region 8p11.2-p12 is consistently amplified in human breast cancer. We have constructed a 2.8 Mb YAC contig of this region, centered on the human Fibroblast Growth Factor Receptor 1 (FGFR1) locus and encompassing the Adrenergic beta 3 Receptor (ADRB3) locus. A smaller centromeric YAC contig spanning 1.4 Mb...

journal_title：Oncogene

authors： Dib A,Adélaïde J,Chaffanet M,Imbert A,Le Paslier D,Jacquemier J,Gaudray P,Theillet C,Birnbaum D,Pébusque MJ

更新日期：1995-03-02 00:00:00

abstract：:We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...

journal_title：Oncogene

authors： Avila MA,Velasco JA,Cho C,Lupu R,Wen D,Notario V

更新日期：1995-03-02 00:00:00

abstract：:SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...

journal_title：Oncogene

authors： Murrell AM,Green AR

更新日期：1995-02-16 00:00:00

abstract：:Apoptotic cell death is an active process which regulates the maintenance of the hematopoietic homeostasis. It has been reported that wild-type p53 (wt-p53) protein induces apoptosis in leukemia cells. To assess whether p53 is involved in the apoptotic process of normal hematopoietic cells, we introduced the temperatu...

journal_title：Oncogene

authors： Blandino G,Scardigli R,Rizzo MG,Crescenzi M,Soddu S,Sacchi A

更新日期：1995-02-16 00:00:00

abstract：:We have cloned and characterised the murine gene encoding c-Mpl, a receptor for thrombopoietin and member of the hematopoietin receptor superfamily. The gene encompasses 15 kb of the mouse genome and the organisation of its 12 exons conforms closely to the pattern observed for the genes of other hematopoietin receptor...

journal_title：Oncogene

authors： Alexander WS,Dunn AR

更新日期：1995-02-16 00:00:00

abstract：:The E6 proteins of specific cancer-associated human papillomaviruses (HPVs) complex with and mediate degradation of the cellular anti-oncogene p53 in vitro. A critical property of p53 is its ability to stimulate transcription from promoters containing its recognition sequence. HPV E6, mutant p53 proteins, and several ...

journal_title：Oncogene

authors： Mansur CP,Marcus B,Dalal S,Androphy EJ

更新日期：1995-02-02 00:00:00

abstract：:The Epstein-Barr virus (EBV) encoded latent membrane protein, LMP1, is oncogenic in rodent fibroblasts and is an essential effector protein in EBV-induced growth-transformation of human B lymphocytes. Previous structure-function studies with LMP1 have relied largely on rodent fibroblast transformation as a functional ...

journal_title：Oncogene

authors： Huen DS,Henderson SA,Croom-Carter D,Rowe M

更新日期：1995-02-02 00:00:00

abstract：:Although loss of sensitivity to transforming growth factor beta (TGF beta) may be a key step in the escape of epithelial tumours from normal growth control, the intracellular signals determining responsiveness remain controversial, particularly the role of p53. We have investigated this question using thyroid epitheli...

journal_title：Oncogene

authors： Blaydes JP,Schlumberger M,Wynford-Thomas D,Wyllie FS

更新日期：1995-01-19 00:00:00

abstract：:Transforming growth factor-beta 1 (TGF-beta 1) inhibits most epithelial cell types by blocking cell cycle progression during the G1 phase. D cyclins are normally expressed during G1 and are regulators of G1 progression. One of the crucial functions of D cyclins is their ability to bind to a cyclin-dependent kinase (Cd...

journal_title：Oncogene

authors： Ko TC,Sheng HM,Reisman D,Thompson EA,Beauchamp RD

更新日期：1995-01-05 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with tumours of both lymphoid and epithelial origin. Whilst a role for EBV latent genes in the development of these malignancies is accepted, it is also possible that viral proteins involved in EBV replication may influence the oncogenic process. BHRF1 is an immediate early prote...

journal_title：Oncogene

authors： Dawson CW,Eliopoulos AG,Dawson J,Young LS

更新日期：1995-01-05 00:00:00

abstract：:We have previously shown that each of four activated oncogenes (c-myc, neu, ras, and int-2) can serve as transgenic initiators of morphologically distinct adenocarcinomas of the murine mammary gland. Since abnormalities of these oncogenes are found frequently in human breast cancers, such differences are of particular...

journal_title：Oncogene

authors： Morrison BW,Leder P

更新日期：1994-12-01 00:00:00

abstract：:The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...

journal_title：Oncogene

authors： La Rocca SA,Crouch DH,Gillespie DA

更新日期：1994-12-01 00:00:00

abstract：:The c-erbB-2 proto-oncogene encodes a receptor tyrosine kinase (RTK) closely related to the epidermal growth factor receptor (EGFR). Overexpression of erbB-2 occurs in approximately 20% of human breast tumours, where increased expression correlates with poor patient prognosis. The EGFR is coupled to the Ras signalling...

journal_title：Oncogene

authors： Janes PW,Daly RJ,deFazio A,Sutherland RL

更新日期：1994-12-01 00:00:00

abstract：:Genetic and biochemical evidence suggest that conserved region 3 (CR3) of the adenovirus Ela polypeptide can provide two distinct and separable functions: an N-terminal transcriptional activation region and a C-terminal promoter targeting region. It is thought that the promoter targeting region of Ela CR3 interacts wi...

journal_title：Oncogene

authors： Agoff SN,Wu B

更新日期：1994-12-01 00:00:00

abstract：:Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor Sp1 in active expression from the promoter, particularly from the -5...

journal_title：Oncogene

authors： Chen X,Wright KL,Berkowitz EA,Azizkhan JC,Ting JP,Lee DC

更新日期：1994-11-01 00:00:00

abstract：:The chicken c-ets-1 locus encodes two transcription factors, p54c-ets-1 and p68c-ets-1 that differ in their N-termini, encoded respectively by the I54 and alpha beta exons. p68c-ets-1 equivalents are only found in birds and reptiles while p54c-ets-1 is widely conserved in vertebrates, from amphibians to mammals. Thus,...

journal_title：Oncogene

authors： Albagli O,Soudant N,Ferreira E,Dhordain P,Dewitte F,Begue A,Flourens A,Stehelin D,Leprince D

更新日期：1994-11-01 00:00:00

abstract：:The viability of rat embryo cells immortalized by thermosensitive mutants of SV40 or polyoma Large T antigen is impaired at the non-permissive temperature thus demonstrating that the immortal phenotype is dominantly maintained by Large T antigens. We have observed that exposing these cells to the restrictive temperatu...

journal_title：Oncogene

authors： Zheng DQ,Vayssière JL,Petit PX,LeCoeur H,Spatz A,Mignotte B,Feunteun J

更新日期：1994-11-01 00:00:00

abstract：:Growth arrest after u.v. damage was investigated in C3H mouse primary cultured hepatocytes, spontaneously immortalized liver epithelial cells and their H-ras-transformed derivatives. All cells except for one of the transformed lines had the wild type p53 gene considered necessary for the G1-S checkpoint. Growth arrest...

journal_title：Oncogene

authors： Kadohama T,Tsuji K,Ogawa K

更新日期：1994-10-01 00:00:00

abstract：:We previously described the isolation of non-tumorigenic revertants from mutagenized populations of v-fos-transformed Rat-1 cells (Zarbl et al., 1987). In the present study we examined the possibility that the revertant phenotype resulted from mutations that altered the expression or activities of the c-jun or junB pr...

journal_title：Oncogene

authors： Van Amsterdam JR,Wang Y,Sullivan RC,Zarbl H

更新日期：1994-10-01 00:00:00

abstract：:Recently, various cDNA sequences coding protein-tyrosine phosphatases (PTPs) have been reported and their extensive similarities in the catalytic domains clarified, but knowledge of the structures and organizations of their genes is still limited. In this study, a detailed structure and organization of the human intra...

journal_title：Oncogene

authors： Adachi M,Miyachi T,Sekiya M,Hinoda Y,Yachi A,Imai K

更新日期：1994-10-01 00:00:00

abstract：:The A-myb gene belongs to the family of the c-myb proto-oncogene. We report here the cloning from a B lymphocyte cDNA library of the previously missing 3' half of the human A-myb cDNA, thus closing the previously still incomplete open reading frame. Analysis of the homologies between the different myb proteins reveals...

journal_title：Oncogene

authors： Golay J,Loffarelli L,Luppi M,Castellano M,Introna M

更新日期：1994-09-01 00:00:00

abstract：:We have isolated mouse cDNA clones encoding Tyro 3, a receptor protein-tyrosine kinase (PTK) of the mammalin central nervous system (CNS). Expression of the Tyro 3 gene is strongly up-regulated in neurons of the mouse neocortex, cerebellum, and hippocampus after the day of birth, during periods of active synaptogenesi...

journal_title：Oncogene

authors： Lai C,Gore M,Lemke G

更新日期：1994-09-01 00:00:00

abstract：:In this study we have surveyed by immunoblotting the protein levels of Cyclin D1, D2, D3 and their catalytic partners, Cdk4 and Cdk6 in normal and transformed human cells. We found that all these proteins were differentially expressed in diploid cells derived from different tissues, in contrast to Cyclin E, Cyclin A a...

journal_title：Oncogene

authors： Tam SW,Theodoras AM,Shay JW,Draetta GF,Pagano M

更新日期：1994-09-01 00:00:00

abstract：:Abnormalities of the p53 tumour suppressor gene occur in many types of cancer including approximately 60% of colorectal carcinomas. This study investigates in 47 colorectal carcinomas the relationship between stabilised p53 protein detected by immunocytochemistry (ICC), and p53 mutation. 27 cases stained positively wi...

journal_title：Oncogene

authors： Cripps KJ,Purdie CA,Carder PJ,White S,Komine K,Bird CC,Wyllie AH

更新日期：1994-09-01 00:00:00

abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...

journal_title：Oncogene

authors： Martinerie C,Huff V,Joubert I,Badzioch M,Saunders G,Strong L,Perbal B

更新日期：1994-09-01 00:00:00

abstract：:Recent studies have revealed that Ras can associate physically with Raf. In the present study, we tested 34 mutants of Ha-Ras carrying substitution(s) in the region of residues 23-71 for their ability to associate with Raf-1. Mouse Ba/F3 cell lysates were incubated with each mutant Ras protein, in either the guanosine...

journal_title：Oncogene

authors： Shirouzu M,Koide H,Fujita-Yoshigaki J,Oshio H,Toyama Y,Yamasaki K,Fuhrman SA,Villafranca E,Kaziro Y,Yokoyama S

更新日期：1994-08-01 00:00:00

abstract：:Oncostatin M (OM) is a polypeptide cytokine that induces autocrine and paracrine effects on AIDS-Kaposi's sarcoma (KS) cells (Nair et al., Science, 255, 1430-1432, 1992; Miles et al., Science, 255, 1432-1434, 1992). The signalling pathways underlying this activation are largely unknown. We have found that OM binding t...

journal_title：Oncogene

authors： Soldi R,Graziani A,Benelli R,Ghigo D,Bosia A,Albini A,Bussolino F

更新日期：1994-08-01 00:00:00

abstract：:In this study we have investigated DNA-protein interactions at an AP1-like motif of the neuropeptide tyrosine (NPY) promoter during in vitro differentiation of human neuroblastoma cells SH-SY5Y to mature nonproliferative sympathetic neuron-like cells. These neuroblast-like cells originate from the parental cell line S...

journal_title：Oncogene

authors： Jalava A,Mai S

更新日期：1994-08-01 00:00:00

abstract：:p53 is a multifunctional protein that has been shown to inhibit the growth of transformed cells, arrest the cell cycle of normal cells, regulate gene transcription and influence cellular differentiation, apoptosis and senescence. This study was undertaken to determine if the expression of p53 in keratinocytes varied d...

journal_title：Oncogene

authors： Spandau DF

更新日期：1994-07-01 00:00:00

abstract：:tal-1 deletions are caused by a site specific recombination, which exclusively occurs in 12-26% of T-cell acute lymphoblastic leukemias (T-ALL). In a previous study on a large series of T-ALL we demonstrated an apparent preferential occurrence of tal-1 deletions in CD3- and CD3+ alpha beta lineage T-ALL with TcR-delta...

journal_title：Oncogene

authors： Breit TM,Wolvers-Tettero IL,van Dongen JJ

更新日期：1994-07-01 00:00:00